Eighteen months have passed since the events of the season 1 finale and a lot has changed at the fictional St Matthew’s Hospital. cardiothoracic surgeon Jenny Bremner (Sarah Parish) now has a baby with anaesthetist Lawrence Shepherd (Tom Riley), there’s a new Head of Clinical Services Alistair Gillespie (Neil Pearson) and Andrew Mullery (Andrew Gower) has transferred to general surgery and is now a registrar.
Changing his specialty has also given a boost of confidence to Mullery, who is now a much more accepted member of staff at the hospital and has become friends with fellow registrar Sarah Witney (Christina Chong). Together with trainees Daniel Springer (Luke Allen-Gale) and Kitty Wilson (Michelle Asante), they have formed a close-knit circle much like the older doctors.
On her first day back at work after maternity leave, Bremner is torn between her guilt as a young mother leaving her baby in the care of a stranger and feeling sidelined after being out of her job for so long. Dr Monroe (James Nesbitt) still struggles with accepting all the differences at work, when his son announces his engagement to girlfriend Donna (Karla Crome).
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